PoplarV1, Main, Exploration, bibRecord, 001752

Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

Identifieur interne : 001752 ( Main/Exploration ); précédent : 001751; suivant : 001753

Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

Auteurs : Gregor E. Berger [Suisse, Australie] ; Stefan Smesny [Allemagne] ; Miriam R. Sch Fer [Australie, Autriche] ; Berko Milleit [Allemagne] ; Kerstin Langbein [Allemagne] ; Uta-Christina Hipler [Allemagne] ; Christine Milleit [Allemagne] ; Claudia M. Klier [Autriche] ; Monika Schlögelhofer [Autriche] ; Magdalena Holub [Autriche] ; Ingrid Holzer [Autriche] ; Michael Berk [Australie] ; Patrick D. Mcgorry [Australie] ; Heinrich Sauer [Allemagne] ; G Paul Amminger [Australie, Autriche]

Source :

PloS one [ 1932-6203 ] ; 2016.

RBID : pubmed:26894921

Descripteurs français

KwdFr :
- Acide nicotinique (métabolisme), Acide nicotinique (pharmacologie), Acides gras (métabolisme), Activation enzymatique (MeSH), Adolescent (MeSH), Adulte (MeSH), Espace intracellulaire (métabolisme), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Peau (anatomopathologie), Peau (effets des médicaments et des substances chimiques), Peau (métabolisme), Phospholipases A2 (métabolisme), Risque (MeSH), Rougeur de la face (induit chimiquement), Troubles psychotiques (métabolisme), Troubles psychotiques (épidémiologie), Troubles psychotiques (étiologie).
MESH :
- anatomopathologie : Peau.
- effets des médicaments et des substances chimiques : Peau.
- induit chimiquement : Rougeur de la face.
- métabolisme : Acide nicotinique, Acides gras, Espace intracellulaire, Peau, Phospholipases A2, Troubles psychotiques.
- pharmacologie : Acide nicotinique.
- épidémiologie : Troubles psychotiques.
- étiologie : Troubles psychotiques.
- Activation enzymatique, Adolescent, Adulte, Femelle, Humains, Jeune adulte, Mâle, Risque.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Enzyme Activation (MeSH), Fatty Acids (metabolism), Female (MeSH), Flushing (chemically induced), Humans (MeSH), Intracellular Space (metabolism), Male (MeSH), Niacin (metabolism), Niacin (pharmacology), Phospholipases A2 (metabolism), Psychotic Disorders (epidemiology), Psychotic Disorders (etiology), Psychotic Disorders (metabolism), Risk (MeSH), Skin (drug effects), Skin (metabolism), Skin (pathology), Young Adult (MeSH).
MESH :
- chemical , metabolism : Fatty Acids, Niacin, Phospholipases A2.
- chemically induced : Flushing.
- drug effects : Skin.
- epidemiology : Psychotic Disorders.
- etiology : Psychotic Disorders.
- metabolism : Intracellular Space, Psychotic Disorders, Skin.
- pathology : Skin.
- chemical , pharmacology : Niacin.
- Adolescent, Adult, Enzyme Activation, Female, Humans, Male, Risk, Young Adult.

Abstract

BACKGROUND

Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.

METHODS

We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.

RESULTS

Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.

CONCLUSIONS

Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.

DOI: 10.1371/journal.pone.0148429
PubMed: 26894921
PubMed Central: PMC4764507

Affiliations:

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Le document en format XML

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<author><name sortKey="Holzer, Ingrid" sort="Holzer, Ingrid" uniqKey="Holzer I" first="Ingrid" last="Holzer">Ingrid Holzer</name>
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<author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name>
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<author><name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name>
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</placeName>
<orgName type="university">Université de Melbourne</orgName>
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<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.</title>
<author><name sortKey="Berger, Gregor E" sort="Berger, Gregor E" uniqKey="Berger G" first="Gregor E" last="Berger">Gregor E. Berger</name>
<affiliation wicri:level="1"><nlm:affiliation>University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich</wicri:regionArea>
<wicri:noRegion>8032 Zurich</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
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<author><name sortKey="Smesny, Stefan" sort="Smesny, Stefan" uniqKey="Smesny S" first="Stefan" last="Smesny">Stefan Smesny</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sch Fer, Miriam R" sort="Sch Fer, Miriam R" uniqKey="Sch Fer M" first="Miriam R" last="Sch Fer">Miriam R. Sch Fer</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Milleit, Berko" sort="Milleit, Berko" uniqKey="Milleit B" first="Berko" last="Milleit">Berko Milleit</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
</affiliation>
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<author><name sortKey="Langbein, Kerstin" sort="Langbein, Kerstin" uniqKey="Langbein K" first="Kerstin" last="Langbein">Kerstin Langbein</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hipler, Uta Christina" sort="Hipler, Uta Christina" uniqKey="Hipler U" first="Uta-Christina" last="Hipler">Uta-Christina Hipler</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University Hospital Jena, Erfurter Straße 35, D-07743 Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology, University Hospital Jena, Erfurter Straße 35, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
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<author><name sortKey="Milleit, Christine" sort="Milleit, Christine" uniqKey="Milleit C" first="Christine" last="Milleit">Christine Milleit</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klier, Claudia M" sort="Klier, Claudia M" uniqKey="Klier C" first="Claudia M" last="Klier">Claudia M. Klier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schlogelhofer, Monika" sort="Schlogelhofer, Monika" uniqKey="Schlogelhofer M" first="Monika" last="Schlögelhofer">Monika Schlögelhofer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holub, Magdalena" sort="Holub, Magdalena" uniqKey="Holub M" first="Magdalena" last="Holub">Magdalena Holub</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holzer, Ingrid" sort="Holzer, Ingrid" uniqKey="Holzer I" first="Ingrid" last="Holzer">Ingrid Holzer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berk, Michael" sort="Berk, Michael" uniqKey="Berk M" first="Michael" last="Berk">Michael Berk</name>
<affiliation wicri:level="4"><nlm:affiliation>Deakin University of Melbourne, School of Medicine, Barwon Health, Geelong, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Deakin University of Melbourne, School of Medicine, Barwon Health, Geelong</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Florey Institute for Neuroscience and Mental Health, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute for Neuroscience and Mental Health, Parkville</wicri:regionArea>
<wicri:noRegion>Parkville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Sauer, Heinrich" sort="Sauer, Heinrich" uniqKey="Sauer H" first="Heinrich" last="Sauer">Heinrich Sauer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>07743 Jena</wicri:noRegion>
<wicri:noRegion>D-07743 Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amminger, G Paul" sort="Amminger, G Paul" uniqKey="Amminger G" first="G Paul" last="Amminger">G Paul Amminger</name>
<affiliation wicri:level="4"><nlm:affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna</wicri:regionArea>
<wicri:noRegion>A-1090 Vienna</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Enzyme Activation (MeSH)</term>
<term>Fatty Acids (metabolism)</term>
<term>Female (MeSH)</term>
<term>Flushing (chemically induced)</term>
<term>Humans (MeSH)</term>
<term>Intracellular Space (metabolism)</term>
<term>Male (MeSH)</term>
<term>Niacin (metabolism)</term>
<term>Niacin (pharmacology)</term>
<term>Phospholipases A2 (metabolism)</term>
<term>Psychotic Disorders (epidemiology)</term>
<term>Psychotic Disorders (etiology)</term>
<term>Psychotic Disorders (metabolism)</term>
<term>Risk (MeSH)</term>
<term>Skin (drug effects)</term>
<term>Skin (metabolism)</term>
<term>Skin (pathology)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide nicotinique (métabolisme)</term>
<term>Acide nicotinique (pharmacologie)</term>
<term>Acides gras (métabolisme)</term>
<term>Activation enzymatique (MeSH)</term>
<term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Espace intracellulaire (métabolisme)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Peau (anatomopathologie)</term>
<term>Peau (effets des médicaments et des substances chimiques)</term>
<term>Peau (métabolisme)</term>
<term>Phospholipases A2 (métabolisme)</term>
<term>Risque (MeSH)</term>
<term>Rougeur de la face (induit chimiquement)</term>
<term>Troubles psychotiques (métabolisme)</term>
<term>Troubles psychotiques (épidémiologie)</term>
<term>Troubles psychotiques (étiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids</term>
<term>Niacin</term>
<term>Phospholipases A2</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Peau</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Flushing</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Peau</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Psychotic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Psychotic Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Rougeur de la face</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Intracellular Space</term>
<term>Psychotic Disorders</term>
<term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide nicotinique</term>
<term>Acides gras</term>
<term>Espace intracellulaire</term>
<term>Peau</term>
<term>Phospholipases A2</term>
<term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Skin</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide nicotinique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Niacin</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles psychotiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Enzyme Activation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Risk</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Adolescent</term>
<term>Adulte</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Risque</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26894921</PMID>
<DateCompleted><Year>2016</Year>
<Month>07</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>02</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS One</ISOAbbreviation>
</Journal>
<ArticleTitle>Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.</ArticleTitle>
<Pagination><MedlinePgn>e0148429</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0148429</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year transition outcome (UHR-T n = 11; UHR-NT n = 55) with healthy controls (HC n = 25) and first episode schizophrenia patients (FEP n = 25) treated with atypical antipsychotics.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Contrary to our hypothesis niacin sensitivity of the entire UHR group was not attenuated, but significantly increased compared to the HC group, whereas no difference could be found between the UHR-T and UHR-NT groups. As expected, niacin sensitivity of FEP was attenuated compared to HC group. In UHR individuals niacin sensitivity was inversely correlated with omega-6 and -9 fatty acids (FA), but positively correlated with phospholipase A2 (inPLA2) activity, a marker of membrane lipid repair/remodelling.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Increased niacin sensitivity in UHR states likely indicates an impaired balance of eicosanoids and omega-6/-9 FA at a membrane level. Our findings suggest that the emergence of psychosis is associated with an increased mobilisation of eicosanoids prior to the transition to psychosis possibly reflecting a "pro-inflammatory state", whereas thereafter eicosanoid mobilisation seems to be attenuated. Potential treatment implications for the UHR state should be further investigated.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berger</LastName>
<ForeName>Gregor E</ForeName>
<Initials>GE</Initials>
<AffiliationInfo><Affiliation>University Hospital of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smesny</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schäfer</LastName>
<ForeName>Miriam R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Milleit</LastName>
<ForeName>Berko</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langbein</LastName>
<ForeName>Kerstin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hipler</LastName>
<ForeName>Uta-Christina</ForeName>
<Initials>UC</Initials>
<AffiliationInfo><Affiliation>Department of Dermatology, University Hospital Jena, Erfurter Straße 35, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Milleit</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klier</LastName>
<ForeName>Claudia M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Schlögelhofer</LastName>
<ForeName>Monika</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holub</LastName>
<ForeName>Magdalena</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holzer</LastName>
<ForeName>Ingrid</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berk</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Deakin University of Melbourne, School of Medicine, Barwon Health, Geelong, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Florey Institute for Neuroscience and Mental Health, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McGorry</LastName>
<ForeName>Patrick D</ForeName>
<Initials>PD</Initials>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sauer</LastName>
<ForeName>Heinrich</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amminger</LastName>
<ForeName>G Paul</ForeName>
<Initials>GP</Initials>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>02</Month>
<Day>19</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>2679MF687A</RegistryNumber>
<NameOfSubstance UI="D009525">Niacin</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.1.4</RegistryNumber>
<NameOfSubstance UI="D054467">Phospholipases A2</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005227" MajorTopicYN="N">Fatty Acids</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005483" MajorTopicYN="N">Flushing</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042541" MajorTopicYN="N">Intracellular Space</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009525" MajorTopicYN="N">Niacin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054467" MajorTopicYN="N">Phospholipases A2</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>07</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>01</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>2</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>2</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>7</Month>
<Day>28</Day>
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Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis.

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